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Prevalence and determinants of Fatigue among Parkinson’s disease patients in Ethiopia

Dereje Melka Oda | Bio
Addis Ababa University, College of Health Sciences
Abenet Tafesse
Addis Ababa University, College of Health Sciences
Solomon Sheferaw
Addis Ababa University, School of public health
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  • Submited: May 30, 2019
  • Published: March 19, 2020

Abstract

ABSTRACT

Purpose:Fatigue is a severe problem for many people living with Parkinson’s disease (PD). Best estimates suggest that more than 50% of PDpatients experience this debilitating symptom.Fatigue is related to disease progression and excessive daytime sleepiness (EDS) and yet there has been no prior report on Fatigue among patients with PD living in Ethiopia. The present study aimed at assessing the prevalence and determinant of fatigue among PD patients in Ethiopia.

 

Methods: A cross-sectional study of all PD patients attending the follow-up clinics of the Departments of Neurology at Tikur Anbessa and Zewditu Memorial Hospital in Addis Ababa, Ethiopia, from July 1 to October 30, 2015 was conducted.We collected information using a structured questionnaire which assessed demographic information, clinical history, the Parkinson’s fatigue scale item_sixteen (PFS-16, distressing fatigue defined asPFS-16 mean score >3.3) and the Epworth Sleepiness Scale (ESS).

 

Results: Of the 155 patients surveyed 155 patients responded for PFS-16 items with mean (+SD) score of 3.88+0.79. Distressing fatigue was noted on 120/151(79.5%) of the respondents. Excessive day time sleepiness, ESS>10(OR 3.39; 95% CI 1.41 - 8.20, p=0.004)and unemployment(OR 2.71; 95% CI 1.19 – 6.17, p=0.016) associated with distressing fatigue.There was no statistical association with age, gender, PD stage, duration of PD symptoms, previous history of sleep disturbance, Levodopa or Trihexyphenidyluse and higher PDSS-2 score.

 

Conclusions: The prevalence of distressing fatigue in Ethiopian PD patientsis substantially high. Further investigations into contributors in our PD patients are needed.

Keywords: Parkinson’s disease, Fatigue, Ethiopia.

 

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References

  1. References
  2. Theresa A. Zesiewicz, Robert A. Hauser. Medical treatment of motor and non-motor features of Parkinson’s disease Continuum: Lifelong Learning Neurol 2007; 13(1):12–38.
  3. Hirtz D, Thurman DJ, Gwinn-Hardy K, MMohamed, parz ARC, Zalutsky R. How common are the “common” neurologic disorders? Neurology. 2007; 68(5):326-37.
  4. Zesiewicz T, Hauser R. Medical treatment of motor and non-motor features of Parkinson’s disease. Continuum: Lifelong Learning Neurol. 2007; 13(1):12–38.
  5. Friedman JH. Chou KL. Sleep and fatigue in Parkinson's disease. Park Relat Disord. 2004; 10(Suppl. 1 :S27-S35.
  6. Falup-Pecurariu C. Fatigue assessment of Parkinson's disease patient in clinic: specific versus holistic. J Neural Transm (Vienna). 2013; 120:577-581.
  7. F. Stocchi, G. Abbruzzese,R. Ceravolo, et.al. Prevalence of fatigue in Parkinson diseaseand its clinical correlates. American Academy of Neurology Neurology 83 July 15, 2014.
  8. Dotchin CL, Msuya O, Kissima J, Massawe J, Mhina A, Moshi A, Aris E, Jusabani A, Whiting D, Masuki G, Walker RW. The prevalence of Parkinson’s disease in rural Tanzania. Movement Disorders 2008 23 (11), 1567-1572.
  9. Dotchin C, Jusabani A, Walker R. Three year follow up of levodopa treatment in a prevalent cohort of patients with Parkinson’s disease in Hai, Tanzania. Journal of Neurology 2011; 258 (9): 1649-56.
  10. Mshana G, Dotchin CL, Walker RW. “We call it the shaking illness”: Perceptions and experiences of Parkinson’s disease in rural northern Tanzania. BMC Public Health. 2011, Apr 8; 11: 219.
  11. Okubadejo NU, Bower JH, Rocca WA, Maraganore DM. Parkinson’s disease in Africa: A systematic review of epidemiological and genetic studies. Movement Disorders. 21 (12), 2150 – 2156 (2006).
  12. Rochester L, Rafferty D, Dotchin C, Msuya O, Minde V, Walker R. Rehabilitation in Parkinson’s disease: The effect of cueing therapy on single and dual-task gait in a drug naïve population in the Hai district of northern Tanzania. Movement Disorders 2010 25 (7) 906-911.
  13. Akinyemi R. Epidemiology of Parkinsonism and Parkinson's Disease in Sub-Saharan Africa: Nigerian profile. J Neurosci Rural Pract 2012 3(3): 233-234.
  14. Okubadejo NU, Ojo OO, Oshinaike OO. Clinical profile of Parkinsonism and Parkinson's disease in Lagos, Southwestern Nigeria. BMC Neurol. 2010; 10:1.
  15. Akinyemi RO, Okubadejo NU, Akinyemi JO, Owolabi MO, Owolabi LF, Ogunniyi A. Cognitive dysfunction in Nigerians with Parkinson's disease. MovDisord. 2008; 23:1378–83.
  16. Haimanot R. Parkinsons disease in Ethiopia - A prospective study of 70 patients. East Afican Medical Journal. 1985;62(8):571-9.
  17. Bower J, Teshome M, Melaku Z, Zenebe G. Frequency of Movement Disorders in an Ethiopian University Practice. Movement Disorders. 2005; 20:1209-13.
  18. Nilsson MH, Bladh S, Hagell P. Fatigue in Parkinson's Disease: Measurement Properties of a Generic and a Condition specificRating Scale. J Pain Symptom Manage. 2013 Mar 15.
  19. Murray W.Johans. A new method for measuring daytime sleepiness: Epworth Sleepiness Scale (ESS) American Sleep medicine. 1991 Dec; 14(6):540-5.)
  20. Kumar S, Bhatia M, Behari M. Excessive day time sleepiness in Parkinson’s disease as assessed by Epworth Sleepiness Scale (ESS). Sleep Medicine 4 (2003) 339–342.
  21. R.G. Browna. A. Dittnera. L. Findleyb . S.C. Wesselyc. The Parkinson fatigue scale. Parkinsonism and Related Disorders 11 (2005) 49–55.
  22. Rao Fu, shi-shuang Cui, Juan-Juan Du, et.al. Validation of the Parkinson fatigue scale in Chinese PD patients. Brain and Behavior. 2017; 7: e00712.
  23. Ioannis E, Efthymia T, Dimitrios K, et.al. The Parkinson fatigue scale: an evaluation of its validity and reliability in Greek Parkinson’s disease patients. Neurological sciences. 2019 Jan; 018-3695-5.
  24. Jian D. Si-Ming J. Yong-Sheng Y. et.al. The Relationship between Fatigue and Other Non-Motor Symptoms in Parkinson's disease in Chinese Population International Journal of Gerontology 11 (2017) 171e175.
  25. Skorvanek M. Nagyova I. Rosenberger J. et al. Clinical determinants of primary and secondary fatigue in patients with Parkinson's disease. J Neurol. 2013; 260: 1554-1561.
  26. Monika GoBdb-Janowska. Dariusz Kotlwga. Krzysztof Safranow. Et.al.Risk Factors of Fatigue in Idiopathic Parkinson’s disease in a Polish Population. Hindawi Publishing Corporation Parkinson’s Disease Volume 2016.
  27. Alves G. Wentzel-Larsen T. Larsen JP. Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology. 2004; 63:1908-1911.
  28. Khedr EM. El Fetoh NA. Khalifa H. et al. Prevalence of non-motor features in a cohort of Parkinson's disease patients. Clin Neurol Neurosurg. 2013; 115: 673-677.
  29. Beiske AG. Svensson E. Fatigue in Parkinson's disease: a short update. Acta Neurol Scand Suppl. 2010; 190:78-81.
How to Cite
Oda, D. M., Tafesse, A., & Sheferaw, S. (2020). Prevalence and determinants of Fatigue among Parkinson’s disease patients in Ethiopia. Ethiopian Medical Journal, 58(02). Retrieved from https://mail.emjema.org/index.php/EMJ/article/view/1325

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